![]() These data support the hypothesis that typical antipsychotics can induce TJMs in rats, and demonstrate that chronic administration of typical antipsychotics is not necessary for induction of TJMs. The jaw movements occurred largely in the 3-7 Hz frequency range characteristic of parkinsonian tremor. Pimozide induced TJMs in a dose-related manner on all days. In the second group of experiments, rats were given single daily injections of pimozide (0.125-1.0 mg/kg) or tartaric acid vehicle for 13 days, and were observed for TJMs on days 1, 7, and 13. As with haloperidol, pimozide failed to suppress tacrine-induced TJMs, even at doses considerably higher than those that suppressed lever pressing. ![]() In the first series of experiments, the effects of acute pimozide on tacrine-induced TJMs and lever pressing were examined. ![]() In order to validate this model with additional drugs, the present studies assessed the effects of the typical antipsychotic pimozide. Moreover, it has been suggested that the relative potency for suppression of tacrine-induced TJMs relative to the suppression of lever pressing can be used to discriminate between typical and atypical antipsychotics. Previous studies demonstrated that the typical antipsychotic haloperidol induced TJMs after acute or subchronic administration, while atypical antipsychotics did not. Drug-induced tremulous jaw movements (TJMs) in rats have been used as a model of parkinsonian tremor.
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